Paediatric amitriptyline overdose
نویسندگان
چکیده
We report a near fatal case of paediatric amitriptyline overdose including a series of ECGs demonstrating the effects of sodium bicarbonate therapy on cardio-toxicity. We briefly discuss the role of sodium to counteract the sodium channel blockade of tricyclic antidepressants and discuss the possible utility of lipid emulsion therapy in such cases.
منابع مشابه
Myocardial infarction: a complication of amitriptyline overdose.
A 22 year old woman was admitted with amitriptyline overdose. Twenty six hours later she developed acute myocardial infarction. Cardiotoxic effects of tricyclic antidepressants are discussed and the importance of considering myocardial infarction as a complication of tricyclic antidepressant overdose is emphasized.
متن کاملCharcoal haemoperfusion in a child with amitriptyline poisoning.
Tricyclic antidepressant (TCA) overdose is a relatively common cause of poisoning. According to the American Association of Poison Control Centers, 7961 patients with amitriptyline poisoning were reported in 2000. Of these, 958 were under 6 years old, 6388 needed treatment in a health care facility and 68 patients died [1]. The current therapy of TCA overdose includes preventive measures such a...
متن کاملA comparison of three computer models for prediction of dose in acute amitriptyline overdose.
The pharmacokinetics of amitriptyline in overdose have been reported not to fit conventional compartmental models. In this study, the dose-concentration-time relationships of amitriptyline in overdose were modeled with discriminant analysis, with an evolutionary heuristic search program, and with a decision-tree model based on the entropy of uncertainty of classification. The computer models al...
متن کاملCommentary: Comparison of activated charcoal and sodium polystyrene sulfonate resin efficiency on reduction of amitriptyline oral absorption in rat as treatments for overdose and toxicities
متن کامل
Comparison of activated charcoal and sodium polystyrene sulfonate resin efficiency on reduction of amitriptyline oral absorption in rat as treatments for overdose and toxicities
Objective(s): Comparative in vivo studies were carried out to determine the adsorption characteristics of amitriptyline (AMT) on activated charcoal (AC) and sodium polystyrene sulfonate (SPS). AC has been long used as gastric decontamination agent for tricyclic antidepressants and SPS has showed to be highly effective on in-vitro drugs adsorption. Materials and Methods: Sprague-Dawley male rats...
متن کامل